DASATINIB-LOADED SOLID LIPID NANOPARTICLES FOR ENHANCED ORAL BIOAVAILABILITY AND CANCER THERAPY
DOI:
https://doi.org/10.29121/44bf1e16Keywords:
Dasatinib, Solid Lipid Nanoparticles, Nano-Oncology, Bioavailability, Targeted Drug Delivery, Tyrosine Kinase InhibitorAbstract
Dasatinib is a second-generation tyrosine kinase inhibitor widely used for the treatment of chronic myeloid leukemia and several malignancies. However, its poor aqueous solubility, limited dissolution rate and extensive first-pass metabolism result in low oral bioavailability and reduced therapeutic efficacy. Nanotechnology-based delivery systems, especially solid lipid nanoparticles (SLNs), have emerged as effective carriers for improving the pharmacokinetic and therapeutic properties of dasatinib. SLNs enhance drug solubility, improve lymphatic transport, prolong systemic circulation and provide controlled release of encapsulated drugs. This study discusses the physicochemical properties of dasatinib, formulation strategies for dasatinib-loaded SLNs, preparation techniques, characterization methods, pharmacokinetic improvements, therapeutic applications and future prospects in nano-oncology.
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